Health Topics — Skin & Topical
Skin & Topical
The skin is one of the most receptor-dense peripheral organs for cannabinoid biology — expressing CB1, CB2, TRPV1, and PPAR-γ across distinct tissue compartments. These articles cover what that receptor landscape means for topical cannabinoid research, what CBG's mechanisms engage at the skin level, and what evidence exists for topical applications to skin and joint tissue.
Start Here — Your Experience
Skin That Won't Calm Down
For the person with eczema, psoriasis, or chronic skin inflammation that conventional treatment hasn't resolved — what the cannabinoid research has examined.
Experience · Plain language
How Topical Cannabinoids Work — and What to Realistically Expect
For the person considering a topical CBD or CBG preparation — how they work in skin tissue and what realistic expectations look like.
Experience · Plain language
Joint Pain and Topical Cannabinoid Applications
For the person with joint pain looking for a topical option — what the research shows about cannabinoids, synovial tissue, and what topical application can reach.
Experience · Plain language
Topical Cannabinoid Application: What Research Shows About Skin Delivery
The skin as an endocannabinoid system organ — receptor distribution, penetration mechanisms, and what research has measured about topical cannabinoid delivery across skin layers.
Pillar anchor · Start here
CBG and Skin: Receptor Expression, Inflammation, and Early Research
The skin expresses CB1, CB2, TRPV1, and PPAR-γ across multiple tissue types — what research shows about CBG's mechanisms across the full cutaneous receptor landscape.
Tier 2 · Preclinical
CBG and Skin Inflammation: Preclinical Research
What keratinocyte cell culture studies have found about CBG and abnormal skin cell proliferation — the mechanism, the findings, and what in vitro evidence can establish.
Tier 2 · Cell culture
CBD and Topical Joint Applications: What the Evidence Shows
Synovial tissue expresses CB2 receptors and transdermal CBD has reached joint tissue in animal models — what the evidence shows and what remains to be established in human research.
Tier 2 · Preclinical & early human